English Name: N,N,N′,N′-Tetramethylethylenediamine (TMEDA)
CAS No.: 110-18-9
Chromatographic Purity: ≥99.0%
Molecular Weight: 116.2
Flash Point: 50 °F
Physical Form: Liquid
Refractive Index: n20/D 1.4179 (lit.)
Density: 0.775 g/mL at 20 °C (lit.)
Applications: Pharmaceutical intermediate
1. Physicochemical Properties
Tetramethylethylenediamine (TMEDA) is a colorless, transparent liquid with a pungent, amine-like odor. It has good volatility and coordination ability. It is volatile and flammable at room temperature, and should be handled in enclosed environments.
Density: 0.775 g/mL (at 20°C)
Boiling Point: 121–122°C
Melting Point: −55°C
Flash Point: 17°C (closed cup)
Refractive Index: n⊃2;⁰ᴰ = 1.421
Solubility: Miscible with most organic solvents such as ethers, alcohols, ether-alcohols, and alkanes; slightly soluble in water.
Stability: Stable under normal temperature and pressure; avoid contact with strong oxidizing agents.
2. Hazard Information
N,N,N′,N′-Tetramethylethylenediamine is classified as a flammable and irritating organic amine. Proper personal protection should be used during handling.
Hazard Class: Class 3 (Flammable Liquid)
UN Number: UN2372
Packing Group: II (Moderate hazard)
GHS Label Elements:
Signal Word: Danger
Hazard Statements:
H226: Flammable liquid
H302: Harmful if swallowed
H312: Harmful in contact with skin
H319: Causes serious eye irritation
H332: Harmful if inhaled
Precautionary Statements:
P210: Keep away from heat, sparks, open flames, and hot surfaces. No smoking.
P280: Wear protective gloves/eye protection/face protection.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for at least 15 minutes. Seek medical advice.
P403+P235: Store in a well-ventilated place. Keep cool.
3. Storage and Transportation
N,N,N′,N′-Tetramethylethylenediamine should be stored in a cool, dry, and well-ventilated warehouse specifically for hazardous chemicals, away from heat and fire sources.
Containers must be tightly sealed and kept out of direct sunlight.
Handle with care to avoid damage to packaging. Prevent leaks during transportation.
Transportation must comply with the International Maritime Dangerous Goods Code (IMDG) and UN Recommendations on the Transport of Dangerous Goods (UNRTDG).
4. Regulatory and Certification Information
REACH (EU): Registered under REACH regulations; SDS and TDS available upon request.
RoHS (EU): Does not contain lead, cadmium, mercury, hexavalent chromium, or PBDEs; compliant with RoHS environmental standards.
China Hazardous Chemical Catalog: Included (refer to official listing for code details).
Customs HS Code: 2921199090 (for reference only; subject to each country's customs classification)