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Introduction to NN Dimethylformamide Dimethyl acetal

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Basic information on N,N-Dimethylformamide dimethyl acetal:

Common name: N,N-Dimethylformamide dimethyl acetal; DMF-DMA;

CAS NO: 4637-24-5

Chromatographic purity: ≥99.0%

Molecular formula: C5H13NO2

Molecular weight: 119.16

Flash point: 45 °F

Density: 0.897 g/mL at 25 °C (lit.)


Main functions: Organic synthesis, pharmaceutical synthesis intermediates, precursor for methenamine synthesis, preparation of 1,2,3-triketones and indoles, condensing agent for quinolone drugs. It can be used in the synthesis of ofloxacin, milrinone, allopurinol, and other drugs. Used as an intermediate for the drug zaleplon. Main function: An important intermediate in organic synthesis.


N,N-Dimethylformamide dimethyl acetal (abbreviated as DMF-DMA) is a compound with significant applications in organic synthesis. Its molecular formula is C5H11NO2, and its structure includes two dimethylformamide groups, enabling it to play a multifunctional role in chemical reactions.


DMF-DMA is a colorless and transparent liquid with the characteristics of low boiling point and low vapor pressure. This makes it an ideal reagent in the field of organic synthesis in laboratories. Its chemical properties of nucleophilicity and catalytic activity allow DMF-DMA to play a unique role in various chemical reactions.


In the field of organic synthesis,DMF-DMA is commonly used as a condensing agent in the synthesis of aldehydes and ketones. By introducing DMF-DMA into the reaction, it can effectively promote the condensation reaction between aldehyde and ketone functional groups, producing corresponding acetal and ketal products. Additionally, DMF-DMA  can also serve as a protective group for functional groups during synthesis, preventing them from unnecessary interference.


Beyond its application in laboratory synthesis, DMF-DMA also plays a significant role in drug synthesis. It can be used to prepare pharmaceutical intermediates, ensuring the efficiency and purity of the reaction. In this process, DMF-DMA not only acts as a condensing agent but also helps to control the selectivity and yield of the reaction.


DMF-DMA also plays the role of a catalyst in certain catalytic reactions. Its nucleophilic properties and relatively high stability make it an effective aid in catalytic reactions, facilitating a range of organic synthesis reactions.


DMF-DMA has a wide range of applications in organic synthesis, but its toxicity and volatility require caution. In laboratory operations, appropriate safety measures should be taken to ensure the safety of personnel. Overall, N,N-Dimethylformamide dimethyl acetal, as a multifunctional organic reagent, provides valuable support for research and industrial applications in the field of organic chemistry.