Methyl 4-Bromobutyrate: FAQ

Basic Information

Synonyms:Methyl 4-bromobutanoate, 4-Bromobutyric acid methyl ester

CAS No:4897-84-1

Molecular Formula:C5H9BrO₂

Molecular Weight:181.03

Physical State:Colorless to pale yellow liquid

Melting Point:175–190 °C

Boiling Point:186–187 °C

Density:1.434 g/mL

Uses:Can be used to prepare cyclopropylmethanamine derivatives, which are important highly active compounds.

1. What is Methyl 4-Bromobutyrate?

Methyl 4-bromobutyrate (CAS: 4897-84-1) is an organic compound with the molecular formula C5H9BrO₂. It belongs to the class of brominated esters. This compound is widely used in organic synthesis, pharmaceutical intermediates, and chemical research. Methyl 4-bromobutyrate exhibits good chemical reactivity, making it an ideal intermediate for many chemical reactions.

2. What are the main applications of Methyl 4-Bromobutyrate?

Methyl 4-bromobutyrate is mainly used in:

Organic synthesis: As an intermediate for synthesizing other chemicals.

Pharmaceutical industry: For the synthesis of drugs and other active compounds.

Agrochemical chemistry: As a raw material in the synthesis of certain agricultural chemical products.

In addition, methyl 4-bromobutyrate is widely used in chemical research and industrial production, especially in bromination and esterification reactions.

3. What are the physical properties of methyl 4-bromobutyrate?

The physical properties of methyl 4-bromobutyrate are as follows:

Molecular Formula: C₅H₉BrO₂

Molecular Weight: 181.03 g/mol

Appearance: Colorless or pale yellow liquid

Density: 1.434 g/mL (20°C)

Melting Point: 175–190 °C

Boiling Point: 186–187 °C

Solubility: Freely soluble in organic solvents such as ethanol and diethyl ether; poorly soluble in water.

4. What are the synthesis methods for Methyl 4-Bromobutyrate?

The synthesis methods for methyl 4-bromobutyrate mainly include:

Bromination reaction: Butyric acid is reacted with bromine to generate 4-bromobutyric acid, which is then esterified with methanol to produce methyl 4-bromobutyrate.

Direct esterification: 4-Bromobutyric acid is reacted directly with methanol to form methyl 4-bromobutyrate.

These synthesis methods are used both in laboratory and industrial scales to produce high-purity methyl 4-bromobutyrate.

5. What are the storage conditions for Methyl 4-Bromobutyrate?

Methyl 4-bromobutyrate should be stored in a cool, dry, well-ventilated area away from direct sunlight. Since it is a volatile chemical, it must be kept in tightly sealed containers. It is recommended to store the product in its original packaging and avoid contact with oxidizing agents, strong acids, or strong bases to minimize the risk of reactions.

6. What is the safety profile of Methyl 4-Bromobutyrate?

Methyl 4-bromobutyrate is a chemical with certain toxicity. The following safety precautions should be taken when handling:

Avoid inhalation: Use appropriate protective equipment such as masks or respirators to avoid inhaling vapors or aerosols.

Avoid skin and eye contact: Wear protective gloves and goggles to prevent direct contact with skin and eyes.

Storage and disposal: Follow relevant chemical safety regulations during storage and disposal to prevent leakage and environmental contamination.

7. How is the purity of Methyl 4-Bromobutyrate tested?

The purity of methyl 4-bromobutyrate can be tested using the following methods:

Gas Chromatography (GC): Separates the compound using a chromatographic column for quantitative purity analysis.

High-Performance Liquid Chromatography (HPLC): Suitable for purity testing in complex solvent systems.

Nuclear Magnetic Resonance (NMR): Confirms molecular structure and performs purity analysis.

Fourier Transform Infrared Spectroscopy (FTIR): Helps confirm compound purity by analyzing characteristic absorption peaks of functional groups.

8. How reactive is Methyl 4-Bromobutyrate with other compounds?

Methyl 4-bromobutyrate exhibits high reactivity, especially in esterification, bromination, and reduction reactions. It reacts with various reducing agents, bases, and nucleophiles to generate a wide range of derivatives. In addition, due to its brominated structure, methyl 4-bromobutyrate is often used as a bromine source in chemical synthesis.

9. Who are the major manufacturers of Methyl 4-Bromobutyrate?

Manufacturers of methyl 4-bromobutyrate are typically chemical companies specializing in organic synthesis intermediates. Producers are widely distributed across the globe, particularly in China, Europe, and the United States. When purchasing, ensure that the supplier has the relevant production qualifications and quality control systems in place.

10. What is the market price of Methyl 4-Bromobutyrate?

The market price of methyl 4-bromobutyrate varies depending on factors such as supply and demand, production scale, and purity. Generally, bulk purchases offer price advantages. It is recommended to contact multiple suppliers and request quotes to obtain competitive pricing.

For more information or technical data sheets on methyl 4-bromobutyrate, please contact us.