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Applications of DMF-DMA in the pharmaceutical field

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Basic information on N,N-Dimethylformamide dimethyl acetal:

Common name: N,N-Dimethylformamide dimethyl acetal; DMF-DMA;

CAS NO: 4637-24-5

Chromatographic purity: ≥99.0%

Molecular formula: C5H13NO2

Molecular weight: 119.16

Flash point: 45 °F

Density: 0.897 g/mL at 25 °C (lit.)

Main Functions

Used in organic synthesis, as a pharmaceutical synthesis intermediate, and as a precursor for methylamine synthesis. It is used in the preparation of 1,2,3-triketones and indoles, and as a condensing agent for quinolone drugs. It can be used in the synthesis of ofloxacin, milrinone, allopurinol, and other drugs. It also serves as an intermediate in the drug zaleplon.


N,N-Dimethylformamide (DMF) and N,N-Dimethylacetamide (DMA) are two colorless and transparent organic solvents, often used in the pharmaceutical field as a mixture (DMF-DMA ). This mixed solvent stands out due to its excellent solubility, chemical stability, and low toxicity, making it an essential tool in the pharmaceutical industry and medical research.


Drug Synthesis and Preparation:

DMF-DMA  plays a crucial role in drug synthesis. Its excellent solubility allows it to effectively dissolve a variety of organic and inorganic substances, facilitating the mixing and reaction of reactants. During key steps of drug synthesis, DMF-DMA  serves as a solvent medium to help increase reaction efficiency and improve product purity.


Drug Delivery Systems:

In the preparation of drug delivery systems, DMF-DMA is commonly used to dissolve carrier materials, drugs, and other auxiliary components. The choice of this mixed solvent benefits from its compatibility with various materials, aiding in the formation of efficient drug delivery systems, and enhancing the bioavailability and therapeutic effect of drugs.


Biomedical Research:

In biomedical research, DMF-DMA  is widely used in bioanalysis and cell culture. Its superior biocompatibility and low toxicity make it a strong candidate for cell culture media. Additionally, its application in analytical techniques such as Nuclear Magnetic Resonance (NMR) allows researchers to more accurately obtain information on the structure of drugs and biomolecules.


Drug Stability Testing:

DMF-DMA  is also used in drug stability testing. Its chemical stability makes it an ideal choice for studying the stability of drugs under different conditions (such as temperature and humidity). By simulating actual storage and usage conditions, it is possible to better understand the long-term stability and shelf life of drugs.


The extensive application of DMF-DMA  mixed solvent in the pharmaceutical field highlights its importance in drug synthesis, delivery system preparation, biomedical research, and toxicological studies. Its exceptional properties make it an indispensable part of the pharmaceutical industry and research field, providing strong support for new drug development and medical research.