+86 025-52110956                                   sales@liskonchem.com

Home » Bolg » reaction between DMF-DMA and methyl groups

reaction between DMF-DMA and methyl groups

Views: 0     Author: Site Editor     Publish Time: 2024-05-24      Origin: Site


facebook sharing button
twitter sharing button
line sharing button
wechat sharing button
linkedin sharing button
pinterest sharing button
whatsapp sharing button
sharethis sharing button

Basic information on N,N-Dimethylformamide dimethyl acetal:

Common name: N,N-Dimethylformamide dimethyl acetal; DMF-DMA;

CAS NO: 4637-24-5

Chromatographic purity: ≥99.0%

Molecular formula: C5H13NO2

Molecular weight: 119.16

Flash point: 45 °F

Density: 0.897 g/mL at 25 °C (lit.)

Main Functions

Used in organic synthesis, as a pharmaceutical synthesis intermediate, and as a precursor for methylamine synthesis. It is used in the preparation of 1,2,3-triketones and indoles, and as a condensing agent for quinolone drugs. It can be used in the synthesis of ofloxacin, milrinone, allopurinol, and other drugs. It also serves as an intermediate in the drug zaleplon.


In the field of organic synthesis, DMF-DMA (N,N-dimethylformamide dimethyl acetal) serves as an important organic synthesis reagent and is widely used in various reactions. Among these, its reaction with methyl groups is a common application. This article will delve into the mechanism of the reaction between DMF-DMA and methyl groups to better understand this key step in organic synthesis.


Basic Properties of DMF-DMA

DMF-DMAis a compound with two active sites, featuring an electrophilic carbon end and a nucleophilic nitrogen end. This structure endows DMF-DMA with rich reactivity, making it widely applicable in organic synthesis.


Mechanism of Reaction Between DMF-DMA and Methyl Groups

The mechanism of the reaction between DMF-DMA and methyl groups involves the reactivity of both the carbon and nitrogen ends.


Carbon end reaction mechanism:

In the methyl reaction, the carbon end of DMF-DMA usually acts as an activator and can be considered a methyl donor. The carbon end can react with electrophilic agents to form intermediates, which then react with the target molecule to transfer the methyl group. In this process, the carbon end of DMF-DMA acts as a catalyst, facilitating the methyl transfer reaction.


Nitrogen end reaction mechanism:

The nitrogen end of DMF-DMA is nucleophilic and can undergo nucleophilic addition reactions with methyl reagents. In this case, the nucleophilicity of the nitrogen end allows DMF-DMA to combine with the methyl reagent to form an intermediate, which then participates in subsequent reaction steps.


Applications and Prospects:

The mechanism of reaction between DMF-DMA and methyl groups is not only applicable to simple methylation reactions but also to complex organic syntheses, such as the synthesis of heterocyclic compounds and drug molecules. Understanding the mechanism of reaction between DMF-DMA and methyl groups helps us design and optimize organic synthesis routes, improving synthesis efficiency and product yield.


In organic synthesis, the reaction between DMF-DMA and methyl groups is an important synthesis method. By thoroughly understanding its reaction mechanism, we can better utilize this organic synthesis tool, contributing to the development and progress of the field of organic synthesis. This article hopes to help readers better understand the mechanism of reaction between DMF-DMAand methyl groups, providing guidance and insights for its practical application.