4-Bromophenylhydrazine Hydrochloride: A Brief Introduction

Basic Information

Synonyms: 4-Bromophenylhydrazine hydrochloride; p-Bromophenylhydrazine hydrochloride  

CAS No.: 622888  

Molecular formula: C6H8BrClN2  

Molecular weight: 223.5  

Appearance: White to light yellow or light gray to light brownbeige crystalline powder  

Melting point: 220–230 °C (dec.)  

Solubility: Soluble in water; slightly soluble in DMSO and methanol

1. Chemical Properties

4-Bromophenylhydrazine hydrochloride, with the molecular formula C6H8BrClN2, is an important organic compound. It usually appears as a white to light yellow crystalline solid and is hygroscopic. Its structure contains a benzene ring with a bromine atom at the para position and a hydrazine group. The hydrazine moiety can react with aldehydes and ketones to form hydrazones, making it useful in carbonyl derivatization and heterocyclic synthesis.

2. Preparation

4-Bromophenylhydrazine hydrochloride can be prepared through the following steps:

 Bromination: Benzene is brominated to produce bromobenzene.

 Nitration: Bromobenzene is nitrated to produce pbromonitrobenzene.

 Reduction: pBromonitrobenzene is reduced under catalytic conditions to produce pbromophenylhydrazine.

 Hydrochloride formation: pBromophenylhydrazine is reacted wi

th hydrochloric acid to form p-bromophenylhydrazine hydrochloride.

3. Applications

4-Bromophenylhydrazine hydrochloride has broad applications in organic synthesis and the pharmaceutical industry. Its main uses include:

 Organic synthesis intermediate: It serves as an important intermediate for the synthesis of various organic compounds.

 Pharmaceutical manufacturing: In the pharmaceutical industry, it can be used as a key intermediate in drug synthesis and participates in the preparation of various pharmaceutical products.

4. Storage and Handling

4-Bromophenylhydrazine hydrochloride should be stored in a cool, dry, and wellventilated place, away from direct sunlight and moisture. Appropriate personal protective equipment should be worn during use. Avoid contact with skin and eyes, and prevent inhalation of dust.

4-Bromophenylhydrazine hydrochloride is an important chemical that has attracted considerable attention due to its wide applications in organic synthesis and the pharmaceutical industry. Understanding its chemical properties, preparation methods, and applications is of great significance for scientific research and industrial production.