4-Bromophenylhydrazine Hydrochloride: Introduction and Applications

Basic Information

Synonyms: 4-Bromophenylhydrazine hydrochloride; p-Bromophenylhydrazine hydrochloride  

CAS No.: 622888  

Molecular formula: C6H8BrClN2  

Molecular weight: 223.5  

Appearance: White to light yellow or light gray to light brownbeige crystalline powder  

Melting point: 220–230 °C (dec.)  

Solubility: Soluble in water; slightly soluble in DMSO and methanol

4-Bromophenylhydrazine hydrochloride is an important organic intermediate widely used in organic synthesis and pharmaceutical R&D. It is a white to light yellow crystalline powder with a certain degree of hygroscopicity. Also known as p-bromophenylhydrazine hydrochloride, it has the molecular formula C6H8BrClN2. Due to its unique structure and chemical properties, it is widely applied in the chemical and pharmaceutical industries.

Physical and Chemical Properties

4-Bromophenylhydrazine hydrochloride is soluble in water and ethanol, and its aqueous solution is acidic. It has strong reducing properties and is easily oxidized in air. Its relative molecular mass is 223.51 g/mol. It is relatively stable at room temperature but may decompose under high temperature or strongly acidic or alkaline conditions.

Applications

Pharmaceutical Intermediates

4-Bromophenylhydrazine hydrochloride is widely used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its reactivity makes it a useful building block for antibacterial, antiviral, and other important drug molecules. In certain synthetic routes, it can effectively improve reaction yield and selectivity.

Organic Synthesis

4-Bromophenylhydrazine hydrochloride is an important reagent in organic synthesis and can be used to prepare various organic compounds. It can act as a nucleophile in substitution reactions to produce a range of bromophenyl-containing compounds, which are widely used in dyes, agrochemicals, and materials chemistry.

Analytical Chemistry

In analytical chemistry, 4-Bromophenylhydrazine hydrochloride  can be used as a reagent for detecting certain metal ions or organic compounds. Its specific chemical reactions can be used to develop sensitive analytical methods for trace target substances.

Materials Science

In recent years, the application of 4-bromophenylhydrazine hydrochloride in materials science has gradually increased. Through structural modification, it can be used to develop functional polymers or nanomaterials with specific properties, showing broad application prospects in electronic devices, biomedicine, and environmental monitoring.

Safety and Storage

4-Bromophenylhydrazine hydrochloride has certain toxicity. Direct contact with skin and eyes should be avoided, and handling should be carried out in a well-ventilated environment. It should be stored in a dry, cool place, away from direct sunlight, strong oxidants, and strong acids or bases.

Due to its unique chemical properties, 4-Bromophenylhydrazine hydrochloride shows broad application potential in many fields. With the development of science and technology, its applications in pharmaceuticals, materials, and chemical synthesis will become increasingly extensive.