An Introduction to Tetrabutylammonium Tribromide

Basic Information of Tetrabutylammonium Tribromide:

Common Names: Tetrabutylammonium tribromide, TBATB

CAS NO: 38932-80-8

Chromatographic Purity: ≥99.0%

Molecular Formula: C₁₆H₃₆NBr₃

Molecular Weight: 482.18

Melting Point: 71-76 °C (lit.)

Density: 1.5469 (rough estimate)

Uses: This product is primarily used as a brominating reagent and catalyst. In organic synthesis, it selectively brominates phenols, aromatic amines, acetylaromatic amines, methyl ketones, alkenes, alkynes, alcohols, and related compounds.

tetrabutylammonium bromide (TBATB, CAS NO: 38932-80-8) is a high-purity (≥99.0% by chromatography) brominating reagent and catalyst widely used in the field of organic synthesis. Renowned for its excellent performance, stable physicochemical properties, and high selectivity, it has become an indispensable tool in modern organic chemical synthesis.

2. Key Product Features

High Purity and Stability

Stringent Quality Standards: Utilizing advanced preparation techniques and rigorous quality control measures, we ensure high purity and stability of the product to meet the demands of both high-precision research and industrial-scale production.

Superior Stability: When stored under appropriate conditions, the product maintains its physicochemical properties over extended periods, minimizing experimental variability caused by quality fluctuations.

Exceptional Catalytic and Brominating Activity

High Selectivity: In organic synthesis, TBATB can selectively brominate a wide range of substrates, including phenols, aromatic amines, acetylaromatic amines, methyl ketones, alkenes, alkynes, and alcohols. This effectively enhances reaction selectivity and yield.

Mild Reaction Conditions: The reagent operates effectively under mild conditions, reducing the risk of side reactions and making it suitable for syntheses that are sensitive to temperature and other reaction parameters.

Versatility

Dual Role as Reagent and Catalyst: It not only participates directly in reactions as a brominating agent but can also act as a catalyst to facilitate reaction progress, playing a dual role in complex organic reaction systems.

Broad Applicability: Suitable for organic bromination reactions, catalytic processes, and multi-step synthetic sequences, it offers greater flexibility in reaction design and pathway optimization for the preparation of complex organic molecules.

3. Primary Application Fields

Organic Synthesis

tetrabutylammonium bromide  plays a vital role in organic chemical synthesis, particularly excelling in the following areas:

Bromination Reactions: It enables the efficient and selective introduction of bromine atoms to generate desired brominated compounds.

Reaction Mechanism Studies: Its unique reactivity profile makes it a valuable research tool for investigating reaction mechanisms and optimizing reaction conditions.

Industrial Manufacturing

Scalable Synthesis: Owing to its efficient and reliable performance, TBATB can significantly improve reaction efficiency and product quality in the industrial-scale production processes of pharmaceuticals, agrochemicals, and fine chemicals.

Green Chemistry: Its ability to facilitate reactions under mild conditions helps reduce energy consumption and byproduct formation, aligning with modern trends in green and sustainable chemistry.

Laboratory Research

Essential Research Reagent: For researchers, this product is an indispensable reagent for studying novel bromination and catalytic reactions. It is commonly employed in experimental validation for academic publications, patents, and the development of new synthetic methodologies.

4. Usage Guidelines and Precautions

Guidelines for Use

Reaction Setup: Select appropriate solvents and conditions based on the nature of the starting materials and the desired product. TBATB is typically used under mild conditions to ensure high selectivity and efficiency.

Catalyst/Reagent Loading Control: As it functions both as a reagent and a potential catalyst, careful optimization of its quantity is necessary in specific reaction designs to avoid excess, which could lead to unwanted side reactions or waste.

Important Precautions

Storage Conditions: Store the product in a cool, dry, and well-ventilated place. Protect from moisture and high temperatures to ensure long-term stability.

Safety Measures: During use, appropriate personal protective equipment (PPE) such as gloves and safety goggles should be worn to prevent potential irritation from substances generated during bromination reactions.

Environmental Responsibility: Dispose of reaction waste and by-products properly in accordance with relevant regulations and safety operating procedures to prevent environmental contamination.

5. Summary of Product Advantages

High Purity: Strict manufacturing protocols and quality testing ensure chromatographic purity of ≥99.0%, providing reliable support for high-precision chemical reactions.

Multifunctionality: Its dual capability as both a direct reagent and a catalyst grants it wider applicability across various fields.

Mild Operational Profile: Effective under mild conditions, it shows distinct advantages in reactions sensitive to temperature and harsh reagents.

Cost-Effectiveness: It offers high value by combining superior quality with competitive pricing, meeting the dual needs of research and industrial production.

With the continuous advancement of organic synthesis technology and the growing emphasis on green chemistry, the application prospects for tetrabutylammonium tribromide in both research and industry are vast. Its characteristics of efficient and selective bromination give it strategic importance in sectors like pharmaceuticals, agrochemicals, and fine chemicals. Moving forward, this product is poised to play an even greater role in enabling the development of new synthetic routes and improving the efficiency of chemical synthesis.

As a high-purity, high-performance brominating reagent and catalyst, tetrabutylammonium tribromide, with its unique reactive advantages and broad applicability, has solidified its position as a key tool in modern organic synthesis. Whether in laboratory research or industrial manufacturing, its high selectivity and mild reaction conditions offer chemists greater possibilities in reaction design. If you are seeking a stable, versatile, and effective brominating reagent and catalyst, tetrabutylammonium bromide  is undoubtedly an ideal choice.

6. Ordering and Support Information

To ensure optimal performance in your specific application, it is recommended to consult the product's Material Safety Data Sheet (MSDS/SDS) for detailed handling and safety information prior to use.

For pricing, bulk order inquiries, or to request a custom purity grade, please contact our sales team. Our technical support specialists are also available to provide assistance with integrating tetrabutylammonium tribromide into your synthetic workflows or to discuss its potential in your research and development projects.