Properties of Tetramethylethylenediamine (TMEDA)

English Name: N,N,N′,N′-Tetramethylethylenediamine (TMEDA)

CAS No.: 110-18-9

Chromatographic Purity: ≥99.0%

Molecular Weight: 116.2

Flash Point: 50 °F

Physical Form: Liquid

Refractive Index: n20/D 1.4179 (lit.)

Density: 0.775 g/mL at 20 °C (lit.)

Applications: Pharmaceutical intermediate

1. Physicochemical Properties

Tetramethylethylenediamine (TMEDA) is a colorless, transparent liquid with a pungent, amine-like odor. It has good volatility and coordination ability. It is volatile and flammable at room temperature, and should be handled in enclosed environments.

Density: 0.775 g/mL (at 20°C)

Boiling Point: 121–122°C

Melting Point: −55°C

Flash Point: 17°C (closed cup)

Refractive Index: n²⁰ᴰ = 1.421

Solubility: Miscible with most organic solvents such as ethers, alcohols, ether-alcohols, and alkanes; slightly soluble in water.

Stability: Stable under normal temperature and pressure; avoid contact with strong oxidizing agents.

2. Hazard Information

N,N,N′,N′-Tetramethylethylenediamine  is classified as a flammable and irritating organic amine. Proper personal protection should be used during handling.

Hazard Class: Class 3 (Flammable Liquid)

UN Number: UN2372

Packing Group: II (Moderate hazard)

GHS Label Elements:

Signal Word: Danger

Hazard Statements:

H226: Flammable liquid

H302: Harmful if swallowed

H312: Harmful in contact with skin

H319: Causes serious eye irritation

H332: Harmful if inhaled

Precautionary Statements:

P210: Keep away from heat, sparks, open flames, and hot surfaces. No smoking.

P280: Wear protective gloves/eye protection/face protection.

P305+P351+P338: IF IN EYES: Rinse cautiously with water for at least 15 minutes. Seek medical advice.

P403+P235: Store in a well-ventilated place. Keep cool.

3. Storage and Transportation

N,N,N′,N′-Tetramethylethylenediamine  should be stored in a cool, dry, and well-ventilated warehouse specifically for hazardous chemicals, away from heat and fire sources.

Containers must be tightly sealed and kept out of direct sunlight.

Handle with care to avoid damage to packaging. Prevent leaks during transportation.

Transportation must comply with the International Maritime Dangerous Goods Code (IMDG) and UN Recommendations on the Transport of Dangerous Goods (UNRTDG).

4. Regulatory and Certification Information

REACH (EU): Registered under REACH regulations; SDS and TDS available upon request.

RoHS (EU): Does not contain lead, cadmium, mercury, hexavalent chromium, or PBDEs; compliant with RoHS environmental standards.

China Hazardous Chemical Catalog: Included (refer to official listing for code details).

Customs HS Code: 2921199090 (for reference only; subject to each country's customs classification)